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BSIG Webinar with Ken Cooper
Thursday, April 19, 2018, 12:00 PM - 1:00 PM EDT
Category: Events

BSIG Webinars Ep5: Simulation-based pharma research with guest Ken Cooper LIVE April 19th, 12-1 PM EDT

The Business SIG is pleased to announce that Ken Cooper will join Seth Cordes and Raafat Zaini for the next episode in their webinar series on Thursday, April 19, 12:00 to 1:00 PM EST. Ken will discuss findings from their HIV clinical trial and the applicability of System Dynamics to disease research in general.
Youtube: https://goo.gl/p8p6Au

Pharmaceutical research is universally acknowledged to be “too costly” (over $2 billion per new drug), “too long” (over a decade to market), and “too ineffective” (one in thousands of candidates make it). A big impediment to progress is the routine focus on narrow “silos” of research, largely ignoring the systems in which human diseases interact with the body. What if you could speed research by simulating long-term chronic systemic conditions in minutes, testing leverage points and combinations of interventions to identify the most likely successful therapies in advance of conventional (expensive) trials? Today, preclinical testing is on mice, pigs, monkeys…and the findings rarely translate well to humans. SD simulation offers important new opportunities to enhance our understanding of the systems of the body, and to identify far more effectively better treatments, even cures, for the most devastating diseases.

On today’s episode our guest Ken Cooper will...

  1. Discuss years of SD work in modeling systems of the human body, focusing on the immune system
  2. Describe the HIV analyses and the first clinical trial ever approved based on SD model analyses
  3. Share observations from initial modeling of…
    1. Autoimmune disorders such as type 1 diabetes…What dynamics lie behind the relapsing-remitting course of T1D, MS, and other autoimmune conditions?
    2. Cancers…How does the immune system fail to stop, and even contribute to, tumor development and metastasis, and why does that offer such promise for systemic cures?
    3. Neurodegenerative disorders such as chronic traumatic encephalopathy…What dynamics explain how modest head trauma can cause CTE years and decades later, and could that have anything to do with Alzheimer’s? (yes)
  4. Discuss the opportunity for SD practitioners to make large scientific, economic and societal impacts with analyses of human biology and disorders

Please share the invitation and bring your questions; we’ll answer them LIVE on the air. Hosts: Seth Cordes and Raafat Zaini

*About our guest:

Ken Cooper has led hundreds of applications of system dynamics modeling over four decades. While leading Pugh-Roberts Associates for over 20 years, Ken pioneered the development of project management modeling, dispute resolution with SD, and led corporate strategy work for senior clients in several industries, including aerospace, automobiles, banking, bioscience, construction, shipbuilding, and telecommunications. His clients have included executives at MasterCard, Fluor, Raytheon, Boeing, Northrop Grumman, Ford Motor Company, IBM, and many others.

Ken is a two-time Edelman Laureate for his modeling work; the Franz Edelman Award from the Institute for Operations Research and Management Science (INFORMS) recognizes the best and highest-impact applications of all management science in the world. His Fluor work won the SDS Applications Award in 2010.

In 2011, Ken turned his focus to human biology, following a lifelong dream to apply system dynamics modeling to understanding and curing the most complex diseases of the body. This work led to the first clinical trial ever approved based on analyses from a computer simulation model. Ken has led the development of models of the human immune system, HIV, type 1 diabetes, cancer, and chronic traumatic encephalopathy.

Ken is the first Vice President, Professional Practice for the System Dynamics Society. He is semi-retired at this writing but works select consulting assignments. Ken received his SB from the Massachusetts Institute of Technology, and his MA from Boston University.