REPLY Physiological Diabetes Models (SD7160)

[SDMAIL Louis Macovsky]

Posted by  "Louis Macovsky" <dynbiosys at verizon.net>

> On the subject of Body Physiology models, has anyone knowledge of
> neurological/brain models?

Wakeland, W. and B. Goldstein. 2005. A computer model of intracranial
pressure dynamics during traumatic brain injury that explicitly models fluid
flows and volumes.  Acta Neurochir Suppl. 95:321-326.

Abstract:
A model of intracranial pressure (ICP) dynamics that uses fluid volumes as
primary state variables is presented, along with clinical data for two
subjects with elevated ICP. The data includes annotations to indicate the
precise timing of clinical changes in cerebral spinal fluid drainage, head
of
bed elevation, and minute ventilation. The response to changes in the
clinical parameters was used to calibrate the model to correspond to
specific
subjects by estimating values for key characteristics such as hematoma
volume
and CSF uptake resistance. The error in mean ICP predicted by the model was
less than 2 mmHg when cerebral spinal fluid is drained and the head of bed
elevation was increased. The error in mean ICP predicted by the model
exceeded 5 mmHg during an episode when the head of bed was decreased and
also
during a reduction in minute ventilation. The estimated values for hematoma
volume and other subject characteristics were plausible but could not be
verified empirically.

This is but one example of SD applied in a quantitative experimental format
of which should not be ignored in the discussion of the other list thread
titled Society Strategy Development.

Two other examples:

Wakeland, W., L. Macovsky, G. An, "A hybrid simulation model for studying
acute inflammatory response," SpringSim 07, Norfolk, VA, March 26-29, 2007.

Wakeland, W.W., E.J. Gallaher, L.M. Macovsky, C.A. Aktipis, "A Comparison of
System Dynamics and Agent Based Simulation Applied to the Study of Cellular
Receptor Dynamics," 37th Annual Conference of the Hawaii International
Complex System Society, January 2004, pp 1381-1390.

Lou 
Posted by  "Louis Macovsky" <dynbiosys at verizon.net>
posting date  Thu, 10 Jul 2008 11:39:54 -0700